内側偏桃体のエストロゲン受容体βを発現する神経細胞の活動は発情雌に対する雄マウスの選好性の表出制御に関わる

・By introducing a new Cre mice line for estrogen receptor beta (ERβ), we described the function of ERβ-expressing neurons in the posterodorsal part of the medial amygdala (MeApd-ERβ+) and characteristics of their neuronal activity during preference tests.
・Using fiber photometry and DREADD techniques we have found that MeApd-ERβ+ neurons have a specific role in receptivity-based (receptive female vs. nonreceptive female) preference but not in sex-based (receptive female vs. intact male) preference in male mice.
・We have also described this specific role of MeApd-ERβ+ neurons is achieved by regulating the neuronal activity of downstream BNSTp neurons during receptivity-based, but not sex-based, preference tests.

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