ネッタイシマカのエクジステロイド生合成に関与するグルタチオンS-転移酵素Noppera-boに作用するフラボノイドの殺幼虫活性の分子作用

・Flavonoids compound, Desmethylglycitein(DMG), which can affect many aspects of insect development and physiology, can exert larvicidal activity against Aedes aegypti.
・An X-ray crystallographic analysis and MD simulation of AeNobo revealed the molecular mechanism through which these flavonoids inhibit AeNobo enzymatic activity.
・The development potential of a novel environment-friendly IGR controls the mosquito population by inhibiting ecdysteroid biosynthesis.

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